There are several IT professions that have the potential to earn six-figure salaries, with or without a college degree. Here are some examples:

1. Software Developer: Software developers are responsible for creating software applications or systems. They design, develop, and maintain software to meet the needs of their clients or organization. The median annual salary for software developers is $110,140, according to the U.S. Bureau of Labor Statistics (BLS).
2. Cybersecurity Analyst: Cybersecurity analysts protect computer systems and networks from cyberattacks and other security breaches. They monitor computer systems for suspicious activity, develop security protocols, and investigate security breaches. The median annual salary for cybersecurity analysts is $103,590, according to the BLS.
3. Cloud Architect: Cloud architects design and oversee the implementation of cloud computing systems for organizations. They are responsible for ensuring that cloud systems are secure, scalable, and efficient. The median annual salary for cloud architects is $124,600, according to salary data from Glassdoor.
4. Data Scientist: Data scientists use data analysis tools and techniques to identify patterns, trends, and insights from large data sets. They apply statistical and machine learning techniques to solve business problems and inform decision-making. The median annual salary for data scientists is $98,230, according to the BLS.
5. Network Architect: Network architects design and implement computer networks for organizations. They are responsible for ensuring that networks are secure, reliable, and efficient. The median annual salary for network architects is $112,690, according to the BLS.
6. IT Manager: IT managers oversee the technology infrastructure and operations of an organization. They are responsible for developing and implementing technology strategies, managing IT staff, and ensuring that technology systems meet the needs of the organization. The median annual salary for IT managers is $146,360, according to the BLS.

In many cases, a college degree is preferred or required for these positions, but there are also opportunities for individuals with certifications or experience in the field to earn six-figure salaries. It's worth noting that salaries can vary depending on factors such as location, industry, and level of experience.